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Explore the highlights of the Main River
Published on 21 Jan 2026
The Main River is perfect for travellers who enjoy charming towns, historic cities, and ever-changing scenery along the water. Whether you’re cruising for the culture, architecture, local wines, or simply the joy of exploring at a relaxed pace, a journey along the Main is full of memorable moments. Here are some of the standout places to discover along this beautiful waterway.
Nestled on the banks of the Main River in Hesse, western Germany, Frankfurt is a vibrant, fast-paced city. As well as being a major financial and transportation hub, the city is home to innovative architecture, a thriving culinary scene, and numerous must-visit cultural attractions. You might find yourself strolling across the Eiserner Steg bridge, immersing yourself in art and history at renowned museums and galleries, or treating your taste buds to a world of flavour at some of the many popular food markets. Admire the blend of historic timber-frame architecture and the modern skyscrapers, featuring some of Germany’s tallest buildings, that make up the unique skyline.
As you journey along the Main River, past grand architecture and hillside vineyards, you‘ll reach Würzburg, a charming historic city in northern Bavaria. A favourite pastime for many is venturing out on a scenic walk, sampling the wine that this region is famous for, and wandering through lively squares like Marktplatz. You might also like to take the opportunity to visit the UNESCO World Heritage-listed Würzburg Residence, an opulent palace surrounded by stunning gardens, and the Marienberg Fortress, perched on a hill overlooking the city, offering spectacular views.
Nuremberg, a major city situated in South-Western Germany, is bursting with medieval charm. With a rich history, including its status as a major city of the Holy Roman Empire and a hub of German Renaissance art, it’s a must-visit destination for those keen to learn more about the past. Widely considered to be an extremely walkable city, it’s great for exploring on foot and taking in the many sights. Some of the popular tourist attractions include Kaiserberg, the Imperial Castle of Nuremberg, Nuremberg Old Town, and St. Lawrence Church.
Bamberg is a vibrant riverside location set just above where the Main and Regnitz rivers meet. Despite being officially classified as a town, many agree it feels much more like a small city. It’s best known for its stunning Old Town, a UNESCO World Heritage Site, with beautifully preserved medieval streets and grand Baroque architecture. Much like Rome, Bamberg is said to be built on seven hills, earning it the nickname Franconian Rome.
Mainz is a lively riverside city set on the banks of the Rhine, where it meets the Main River, making it a natural starting point for many Main River journeys. You might spend your time here wandering through the charming Old Town, brimming with historic half-timbered buildings, cosy wine taverns, and impressive churches. The city is also famous for its connection to Johannes Gutenberg, the inventor of the printing press, with the excellent Gutenberg Museum being one of its standout attractions.
Located just southeast of Frankfurt, Offenbach is a laid-back city on the Main River that often surprises visitors with its creative side, thanks to its long history linked to leather goods and design. Today, it is recognised for its artsy atmosphere and mix of modern and traditional architecture. With scenic riverside paths and a slower pace than its big city neighbour, Offenbach makes a refreshing stop along the route.
Miltenberg is a picturesque small town tucked along a bend in the Main River, surrounded by rolling hills and forested countryside. Known for its beautifully preserved medieval centre, it is filled with narrow cobbled streets, charming timber-framed houses, and postcard-worthy squares. One of its most famous sights is the historic market square, which looks like something straight out of a fairytale and is a favourite spot to stop for a drink and soak up the atmosphere.
Wertheim is a charming town at the confluence of the Main and Tauber rivers, offering a mix of history, scenery, and classic German character. It’s most recognised for the ruins of Wertheim Castle, which sit high above the town and provide sweeping views across the river valley. With its colourful old buildings, riverside setting, and relaxed feel, Wertheim is a lovely place to explore on foot and a true highlight on a Main River cruise.