Piraeus (Athens) to Civitavecchia (Rome)

Magnificent Athens combines the fascinations of the ancient world with unique modern architecture.

Shaped like a scythe, the island of Corfu is considered one of the Mediterranean's best-kept secrets. Its lush interior is covered in cypress and olive trees while the main downtown area has elegant Venetian architecture and a serene atmosphere.

On the western coast of Montenegro, tucked away from the Adriatic Sea, is the ancient town of Kotor. Beyond its snaking stone walls, this fortified city offers a charming glimpse back in time.

In Croatia, the Old Town of Split wraps around the luxurious palace where the Roman emperor Diocletian lived out his last days after abdicating in AD 305. Today, this remarkable white limestone palace, a UNESCO Site, awaits your discovery. Part luxurious villa, part military camp, the palace is enclosed by imposing walls and connected by roads linking the eastern Silver Gate with the Iron Gate to the west. Within: an octagonal domed mausoleum, temples and a monumental court accessing the imperial apartments.

Trieste is the capital city of the Friuli Venezia Giulia region in northeast Italy. A port city, it occupies a thin strip of land between the Adriatic coast and Slovenia’s border on the limestone-dominated Karst Plateau. Italian, Austro-Hungarian and Slovenian influences are all evident in its layout, which encompasses a medieval old city and a neoclassical Austrian quarter.

On the southern end of Croatia's Adriatic coast, Dubrovnik staked its claim to glory during the 450 years it existed as the independent Ragusan Republic, shoulder to shoulder with mighty forces like Venice and the Ottoman Empire. Once a renowned seafaring, shipbuilding and trading center, today it's an enchanting tourist destination. Dubrovnik seduces sightseeing visitors with its polished (and very clean!) limestone streets, theatrical architecture, charming café, welcoming restaurants and distinctive shops along scenic side streets. The natural backdrop, much of which is protected, consists of pine and cypress forests and the shimmering Adriatic, dotted with uninhabited islands. Visitors quickly discover that the wider Dubrovnik area is just as striking as its main attraction—the Old Town. A wander around the historic heart of Dubrovnik can hit the main sights, but take it a step further (or a staircase further, really), and you'll see that people do still live in the historic quarter, even though its polished streets make it look like a museum. You may catch the sound of a piano from the High School of Music and Arts, or hear the Dubrovnik Symphony Orchestra rehearsing in the Revelin Fortress, or encounter school kids on a break. Life unrolls as you stroll past.

While travelers have been visiting the Albanian Riviera since antiquity, the region is, with reason, often described as up-and-coming. Long overlooked because of Albania's political isolation from the rest of Europe, this 80-kilometer (50-mile) stretch of the northern Ionian Sea has seaside towns and stunning blue waters that visitors are now rediscovering. Strange concrete pillboxes are still visible, but other vestiges of the Communist era are thankfully fading away. The southern anchor of this coast is Sarandë, whose ancient inhabitants were said to be the descendants of the ancient Greek hero Achilles. Today, the city has become a proverbial boomtown, with the population tripling in summer. Less than 10 miles from the popular Greek tourist island of Corfu, Sarandë now sees plenty of day-trippers coming over on the short ferry ride. With a smooth horseshoe curve to its waterfront, and with fine palm-lined promenades upon which young honeymooners stroll, one wonders: What took so long? Like a mini San Francisco, the city is built around a series of stairs that lead from the top of the hill, dominated by a castle, down to the seafront. Its easy access to the sea helps explain the city’s reputation for serving excellent, fresh seafood. Sarandë is also a convenient base from which to visit a plethora of ancient ruins and UNESCO World Heritage Sites.

Built on the northernmost point of Mirabello Bay, the picturesque port town of Aghios Nikolaos welcomes you with beautiful beaches and a cosmopolitan atmosphere. Enjoy authentic Greek food by the bay in this town that has existed since the 3rd century BC.

Messina's astrological clock is as much a man-made masterpiece as the road leading to Taormina, which canitlevers out of the rocky cliff face and stands on impossibly tall pylons. Leave it to the Italians to design a road that's both a thrill-ride and a feat of engineering! Once you're safely in Taormina, walk to the sublime Greco-Roman theatre that overlooks Naxos Bay and snow-capped Mt Etna, and spend some time on the Corso Umberto with a gelato firmly in hand.

Rising behind the wide curve of its bay with brooding Mount Vesuvius and the deep blue sea as a backdrop, Naples, Italy enjoys a magnificent natural setting. It is the third-largest city in Italy after Rome and Milan, and arguably the most colorful and seductive of them all: Splendor and squalor live side by side in 21st-century Naples, and the mix is intoxicating. Cruise to Naples, home to world-class museums and attractions. Naples has something for everyone - superb restaurants, eclectic shopping, a thriving contemporary art scene and an edgy and vibrant street life. But once you’ve had enough of the pounding traffic and jostling crowds while sightseeing in Naples, there are endless opportunities for exploration further afield. The celebrated Roman ruins of Pompeii and Herculaneum, both victims of Vesuvius’ devastating 79 C.E. eruption, lie just south of the city. Explore Naples' history or take a short ride over to the island of Capri on a Naples shore excursion. The delightful town of Sorrento and the magnificent scenery of the Amalfi Coast are also within easy reach, and the dolce vita glamour of Capri—not to mention the healing thermal waters of Ischia—are a short hydrofoil hop from the mainland. Naples cruises offer a perfect mix of cultural and natural attractions.

When you embark on a cruise to Rome with Holland America Line you experience its bustling modernism along with its rich history. You can walk in the footsteps of emperors, have coffee in Renaissance piazzas and see contemporary art all in one afternoon. Your sightseeing time in Rome begins at the nearby port of Civitavecchia, a seaside town with roots that stretch back to the Etruscan era. Take note of the Forte Michelangelo (both Bramante and Michelangelo had a hand in its design), and the lungomare, a lively stretch along the sea with beach clubs, bars and restaurants. Once in the Eternal City you can fill your day with museums, churches, archaeological sites, traditional trattorias, artisan shops and, of course, gelato. The Colosseum and the Vatican Museums are Rome's superstar attractions, but there are plenty of quieter gems to explore. For food lovers there are the markets in Campo de' Fiori or the slightly farther flung Testaccio. The hip neighborhood of Monti, next to the Colosseum, has a vibrant piazza scene and boutique shopping, while the Villa Borghese offers a green oasis with a view towards Saint Peter’s Basilica and the masterpiece-filled Galleria Borghese. Although Rome might not have been built in one day, you'll certainly be able to see its highlights on our Rome cruises along with the top things to do there in 24 hours.