Ft. Lauderdale to San Antonio (Santiago), Chile

Nestled along the sun-drenched shores of Florida's Atlantic coast, Fort Lauderdale beckons with its pristine beaches, vibrant culture and world-class amenities.

Tropical beaches with coral-rich waters, friendly locals and cheeky green monkeys characterise blissful Barbados.

Devil's Island, part of a three-island chain called Îles du Salut, in French Guiana, was home to one of the most infamous—and impregnable—prisons of the 19th and 20th centuries. Opened in 1852, it received worldwide renown in the mid-1890s when French military captain Alfred Dreyfus was sentenced to life imprisonment after being wrongly convicted of selling military secrets to Germany. Although Dreyfus's sentence was commuted after five years, more than 80,000 political prisoners and hardened criminals endured years of mistreatment and abuse among disease-ridden conditions. Few were able to escape, though Henri Charrière, author of the book Papillon, allegedly succeeded by filling sacks with coconuts in order to float to the mainland. The prison was officially closed in 1953. In 1965, the French government transferred responsibility of the island to the Guiana Space Centre, and in recent years, tourism facilities have been added. Devil's Island and its two smaller neighboring islands receive more than 50,000 visitors each year.

Founded in 1616 as one of the first settlements along Brazil's Amazon River, Belém, the capital of the Brazilian state of Pará, once prospered as one of South America's spotlight playgrounds for the rich and cultured. This urban oasis in the jungle experienced unprecedented growth and fortune during the rubber boom at the turn of the 19th century thanks to a Brazilian monopoly on latex. It was during this golden era that the City of Mango Trees constructed one of its most important landmarks, the neoclassical-style 1874 Theatro da Paz on the Praça da República—an architectural testament to the opulence of those days when the city was affectionately referred to as "the tropical Paris." By 1910, rubber had crashed, but Belém soldiered on as a thriving river port and tourism hub. Today, it's a thoroughly pleasant—albeit sweaty—gateway to the Amazon, made prettier by mango tree–shaded green spaces. The streets of the vibrant historical center are crowded with palatial 17th- and 18th-century buildings, many of which have been turned into seriously wonderful museums. Belém's biggest attraction, however, is the endlessly fascinating, action-packed Ver-o-Peso market, the largest open-air market in Latin America and the requisite first stop for any visitor. From here, Belém's culinary magic becomes apparent: The city's long list of excellent restaurants steeped in unique, jungle-fueled culinary traditions has made Belém one of the most exciting gastronomic destinations in Brazil. Bom proveito!

With Recife's receding tide comes a most unusual bathing beach, dotted with a myriad of inviting pools and a surreal seascape of reef rocks. Hence the name Recife, which means reef. Discover nearby Olinda, a colonial gem beautifully preserved in pastel shades of stucco

Hot all year round and with a tropical rainforest extending down to the sea, it’s easy to understand why Rio de Janeiro is known as “Cidade Maravihosa” (“The Marvellous City”).

Known as the St. Tropez of Uruguay for its miles of beautiful, pristine beaches, sports activities, shopping, and temperate climate, Punta del Este offers something for everyone. Choose a gentle bayside beach or dramatic Atlantic beach with perfect surfing waves; explore the colonial and modern architecture of downtown and shop for local treasures; and visit Casa del Pueblo – a modern art museum that was once the home of celebrated Uruguayan artist Carlos Paez Vilaro.

Buenos Aires, the vibrant capital of Argentina, dances to the rhythm of tango and pulses with cultural energy.

Founded as a Spanish citadel in the eighteenth century, Montevideo has grown into a bold, intellectual and cosmopolitan city.

Perched on the windswept shores of the Falkland Islands, Stanley beckons with its remote charm and rugged beauty.

Nestled at the southernmost tip of Argentina, Ushuaia stands as the gateway to the wild and untamed landscapes of Tierra del Fuego.

If Punta Arenas exudes an "edge of the world" air, it's not without reason. This windblown city near Chile's southernmost tip sits on the Strait of Magellan, which itself is positioned squarely between the Atlantic and Pacific oceans. The city has played—and continues to play—an important role in geographic, political and economic affairs in South America's so-called Southern Cone, which is formed by Chile and neighboring Argentina. Too many travelers rush through Punta Arenas, treating it as a pit stop on their way to the stunningly beautiful landscapes of Torres del Paine National Park and other attractions in Patagonia, but there's plenty in this city and its environs to experience, too. From penguin spotting on Isla Magdalena and kayaking the Strait of Magellan to visiting area farms and then indulging in surf-and-turf specialties (here meaning fresh seafood and asado, or Chilean barbecue) at local restaurants, Punta Arenas is worth a stopover all its own.

Gateway to the scenic Lake District, a series of fragrant eucalyptus and pine forests, icy lakes, Bavarian hamlets and luminous snowcapped volcanoes. Sample shore excursions: Alerce Mountain Lodge & Lake of Reflections; Petrohué Rapids & Frutillar.

This large, modern port serves Chile’s capital, Santiago, a city with Spanish colonial charm and a vivacious spirit. Encircled by the Andes and the Coastal Range, Santiago is centered around the Plaza de Armas, with several of the city’s landmarks: the 18th-century Metropolitan Cathedral the Palacio de la Real Audencia from 1808, the City Hall and the National Museum of History. North of San Antonio lie the picturesque old port and university town of Valparaíso and the colorful seaside resort of Viña del Mar. In between the coast and the capital are valleys filled with some of Chile’s most famous wineries, all inviting you to come and taste.